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Monograph
FDA CAT. 1P-011
Hormones

Sermorelin

29-amino acid GHRH analog. Stimulates pulsatile endogenous growth hormone release; gentler than synthetic GH.

EstablishedHormones
Typical dose200-500 µg
Frequencynightly, subcutaneous
Half-life0.2h
Citations indexed67
DeliveryInjectable
Half-life~12min
EvidenceEstablished
Citations67
Synergy checkCompareReconstitution calc
Mechanism

GHRH(1-29). Originally FDA-approved as Geref for pediatric GH deficiency (withdrawn 2008 commercially). Now produced via 503A compounding for adult anti-aging clinics. Triggers physiologic pulsatile GH release rather than the supraphysiologic spike of recombinant HGH.

Specifics
Body composition (lean mass)Sleep quality / depthLow energy / fatigueLibido / sexual function
Caveats

Original Geref withdrawn for commercial reasons, not safety. Compounded sermorelin quality varies; verify pharmacy accreditation (PCAB / NABP).

sequence · 29 aa
YADAIFTNSYRKVLGQLSARKLLQDIMSR

GHRH(1-29).

Evidence levelEstablished
Regulatory statusFDA Cat. 1 — compounding pharmacies
DNA / pharmacogenomicsModerate — GHRHR variants relevant; clinical PG protocols not standard.
Pairs & ConflictsCheck full stack →
Redundant with

Same mechanism class — adds cost without adding signal.

CJC / IPATesamorelin
Claims & evidence

Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.

  • BModerate evidence

    Sermorelin — primary mechanism: 29-amino acid ghrh analog. stimulates pulsatile endogenous growth hormone release; gentler than synthetic gh.

    2 supporting referencesVerified 5d ago
References

External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.

  • PubMedEN
    REVIEWFunding undisclosedVerified 5d ago
    PubMed — Sermorelin
  • RegulatoryEN
    REGULATORYFunding undisclosedVerified 5d ago
    FDA bulks list (compounding context)
Reconstitution calculatorSermorelin

Pre-filled with this compound's published dose range: 200-500 µg · nightly, subcutaneous

Concentration2.50 mg/mL
Draw volume0.140 mL
Insulin syringe14.0 u
Doses per vial14
U-100 syringe — fill to indicatorU-100 · 1 mL
0u25u50u75u100u

Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.

Supply chain

Public-source attribution across the production + distribution chain. Stack does not endorse vendors — this is who is in the chain, not which one is best.

API manufacturers

  • Bachem AG

    CH
    VERIFIEDFDA REGISTERED

    Swiss-headquartered global peptide API manufacturer with FDA-registered facilities. Supplies APIs to multiple FDA-approved drug brands.

    Source: Bachem — peptide API drug substance manufacturerVerified 5d ago
503A compounding pharmacies (US)

  • Empower Pharmacy

    US
    VERIFIEDPCAB ACCREDITED

    BPC-157 · TB-500 · Sermorelin · CJC-1295/Ipamorelin · Semaglutide · Tirzepatide

    Houston-based 503A compounding pharmacy, one of the largest in the US peptide compounding market.

    Source: Empower Pharmacy — peptide compoundingVerified 5d ago

  • Tailor Made Compounding

    US
    VERIFIEDPCAB ACCREDITED

    BPC-157 · TB-500 · Sermorelin · CJC-1295/Ipamorelin

    Source: Tailor Made CompoundingVerified 5d ago

  • Olympia Pharmaceuticals

    US
    VERIFIEDPCAB ACCREDITED

    BPC-157 · Sermorelin · CJC-1295/Ipamorelin

    Source: Olympia Pharmaceuticals — compounding pharmacyVerified 5d ago

  • Strive Pharmacy

    US
    SELF-REPORTEDPCAB ACCREDITED

    Sermorelin · Ipamorelin · BPC-157

    Source: Strive PharmacyVerified 5d ago
Research-grey channels

  • Peptide Partners

    Research
    3rd-party COA per batchFinnrick ✓US · CA · AU · UK

    One of the most consistently recommended vendors on r/Peptides since the Peptide Sciences shutdown (March 2026). Third-party COA published per batch. HPLC purity ≥99%.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Paradigm Peptide

    Research
    3rd-party COA per batchFinnrick ✓US · CA

    Long-established US vendor (7+ years). Broad catalog including GHRPs, GHRHs, and cognitive peptides. Third-party HPLC and mass-spec COA per batch. Active Finnrick Analytics coverage.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Orbitrex Peptides

    Research
    3rd-party COA per batchUS

    Newer vendor with fast turnaround and competitive pricing. Third-party COA on all products. Building Finnrick coverage. Frequently recommended post-Peptide Sciences shutdown.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Polaris Peptides

    Research
    3rd-party COA on requestFinnrick ✓US · CA

    Established vendor with multi-year community track record. Offers peptide blends (Wolverine Stack, etc.) alongside singles. Third-party COA available on request.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • XL Peptides

    Research
    3rd-party COA per batchFinnrick ✓US · CA · AU

    Known for above-average catalog depth, including harder-to-find compounds (SS-31, humanin, Foxo4-DRI). Third-party HPLC published. Active Finnrick coverage.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Core Peptides

    Research
    3rd-party COA on requestUS

    Clean storefront, competitive pricing, strong community mentions. Third-party COA on most products. Ships to US with fast turnaround.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

  • Defy Medical

    Telehealth
    3rd-party COA per batchUS

    Tampa-based telehealth clinic specializing in hormone and peptide therapy. Prescribing provider + compounding pharmacy fulfillment. BPC-157, CJC/Ipa, Ipamorelin, PT-141, Sermorelin. Prescription required.

    For laboratory use only / not for human consumption. Stack may earn affiliate commissions.

FDA CAT. 1P-011

FDA Cat. 1 — compounding pharmacies

Sermorelin200-500 µg · nightly, subcutaneous
Discussion guide, not prescription

stack is an exploration engine. Output is a discussion guide for a conversation with a licensed provider — never a prescription, dose recommendation, or sourcing instruction. Peptides discussed include compounds with limited human evidence and varying legal status by jurisdiction. Verify everything with a qualified clinician before any decision.

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