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Monograph
FDA APPROVEDP-010
Hormones

Tesamorelin

Stabilized GHRH analog. FDA-approved for HIV-related visceral adiposity; off-label for body composition.

EstablishedHormones
Typical dose1-2 mg
Frequencydaily, subcutaneous
Half-life0.5h
Citations indexed96
DeliveryInjectable
Half-life~30min
EvidenceEstablished
Citations96
Synergy checkCompareReconstitution calc
Mechanism

Trans-3-hexenoyl-stabilized GHRH(1-44). Approved as Egrifta SV for HIV-associated lipodystrophy. RCTs show 11-18% reduction in visceral adipose tissue over 6 months. Off-label use for general body recomposition is widespread; cardiovascular and IGF-1 monitoring recommended.

Specifics
Body composition (lean mass)
Caveats

FDA-approved indication is HIV lipodystrophy. Off-label cosmetic body-recomp use carries IGF-1 elevation; periodic labs prudent. Cost is significant.

sequence · 29 aa
YADAIFTNSYRKVLGQLSARKLLQDIMSR

Stabilized with a trans-3-hexenoyl group at the N-terminus.

Evidence levelEstablished
Regulatory statusFDA approved (Egrifta) — off-label use common
DNA / pharmacogenomicsModerate — Same GHRHR variant context as CJC. Approved indication does not yet incorporate PG screening.
Pairs & ConflictsCheck full stack →
Redundant with

Same mechanism class — adds cost without adding signal.

CJC / IPASermorelinHGH
Where the experts disagree

Stack doesn't rank peptides — we surface the diversity of opinion. Each card paraphrases a public-record stance from a named source. Where they conflict is where you should slow down and read both.

RCT / meta-analysisFalutz et al., NEJM 2007 — Tesamorelin Phase 3 in HIV lipodystrophy

Phase 3 trials showed significant reduction in visceral adipose tissue in HIV-infected adults with lipodystrophy. Effect size led to FDA approval (Egrifta) in 2010. Off-label use for body-recomposition extrapolates from this mechanism without dedicated trials.

Source →
Biohacker / coachEric Janicki, bodybuilding coach (YouTube tier-list, 2026)· 2026-04

B-tier with substantiated human data — "if you're going to take one, either take a Tesa+Ipamorelin blend or just a Tesamorelin." Argues exogenous GH at competitive prices ($200-300/mo) often beats Tesamorelin on cost-per-effect.

Claims & evidence

Per-claim grading. Each claim is graded independently — same peptide, different claims can carry different grades.

  • AStrong evidence

    Tesamorelin reduces visceral adipose tissue in HIV-associated lipodystrophy

    1 supporting referencesVerified 5d ago
  • AStrong evidence

    Tesamorelin contraindicated in active malignancy due to IGF-1 elevation

    0 supporting referencesVerified 5d ago
References

External links to PubMed searches, ClinicalTrials.gov, and FDA materials. We do not host papers — we point at canonical sources.

  • RegulatoryEN
    REGULATORYFunding undisclosedVerified 5d ago
    FDA Egrifta SV label
  • PubMedEN
    REVIEWFunding undisclosedVerified 5d ago
    PubMed — Tesamorelin trials
  • ReviewES
    REVIEWFunding undisclosedVerified 5d ago
    SciELO — tesamorelina (Latin American context)
Reconstitution calculatorTesamorelin

Pre-filled with this compound's published dose range: 1-2 mg · daily, subcutaneous

Concentration2.50 mg/mL
Draw volume0.600 mL
Insulin syringe60.0 u
Doses per vial3
U-100 syringe — fill to indicatorU-100 · 1 mL
0u25u50u75u100u

Calculator is a discussion tool. Verify reconstitution + dosing with a qualified provider. Stack is not a prescription source. Use sterile technique and inspect every vial.

First cycle costCheapest legal from $120

How much a first cycle actually costs across the channels people use. Pick the protocol length you're considering — Stack multiplies the monthly band by cycle weeks. Same caveats apply: ranges are facts, quality varies, this is not legal advice.

MX magistral (compounded)$120–$280
503A compounded (US)$180–$380
FDA-approved brand$3800–$4500

Numbers reflect publicly-advertised price ranges, not vendor quotes. Insurance, prescription costs, and shipping aren't included. Channels marked unavailable are filtered out.

See pharmacies for this compound →
Price across channelsRange $120–$4500/mo

Approximate monthly cost across the channels users actually consider — brand FDA-approved retail, US 503A compounding, Mexican pharmacies, MX farmacias magistrales, and the research-grey market. Stack lists ranges, not vendor names. Quality varies wildly across channels — see each band's note.

Dosing assumption: 1-2 mg daily subcutaneous (off-label body-recomp dose; FDA-approved indication is HIV lipodystrophy at 2 mg)

FDA-approved brand$3800–$4500/mo

Egrifta SV brand. Insurance covers HIV-lipodystrophy indication only; off-label use is cash-pay.

As of 2026-04
503A compounded (US)$180–$380/mo

Wide availability at 503A pharmacies with prescription. Order-of-magnitude cheaper than brand for off-label use.

As of 2026-04
MX magistral (compounded)$120–$280/mo

MX farmacias magistrales prepare Tesamorelin under broader latitude than US 503A.

As of 2026-04
Supply chain

Public-source attribution across the production + distribution chain. Stack does not endorse vendors — this is who is in the chain, not which one is best.

API manufacturers
  • Bachem AG

    CH
    VERIFIEDFDA REGISTERED

    Swiss-headquartered global peptide API manufacturer with FDA-registered facilities. Supplies APIs to multiple FDA-approved drug brands.

    Source: Bachem — peptide API drug substance manufacturerVerified 5d ago
  • CordenPharma

    DE/US/IT
    VERIFIEDFDA REGISTERED

    Multi-region peptide API manufacturer with reactor capacity from 20 L to 28,000 L.

    Source: CordenPharma — peptide APIsVerified 5d ago
Pharma brands (FDA-approved)
  • Egrifta(Theratechnologies)

    CA
    FDA APPROVED 2010

    HIV-associated lipodystrophy / abdominal fat reduction (FDA approved 2010)

    Source: Theratechnologies — EgriftaVerified 5d ago
503A compounding pharmacies (US)
  • Empower Pharmacy

    US
    VERIFIEDPCAB ACCREDITED

    BPC-157 · TB-500 · Sermorelin · CJC-1295/Ipamorelin · Semaglutide · Tirzepatide

    Houston-based 503A compounding pharmacy, one of the largest in the US peptide compounding market.

    Source: Empower Pharmacy — peptide compoundingVerified 5d ago
  • Tailor Made Compounding

    US
    VERIFIEDPCAB ACCREDITED

    BPC-157 · TB-500 · Sermorelin · CJC-1295/Ipamorelin

    Source: Tailor Made CompoundingVerified 5d ago
FDA APPROVEDP-010

FDA approved (Egrifta) — off-label use common

2020MXGuidance

Mexican farmacias magistrales operate under broader compounding latitude than US 503A

COFEPRIS regulates Mexican farmacias magistrales (compounding pharmacies) under different rules than the US 503A bulks-list framework. Several Mexican compounding pharmacies prepare BPC-157, TB-500, CJC-1295/Ipamorelin, Tesamorelin, and GHK-Cu without the FDA Category 2 ban that has constrained US compounding since 2023.

Nov 10, 2010USApproval

Tesamorelin (Egrifta) FDA-approved for HIV-associated lipodystrophy

FDA approved Tesamorelin (Egrifta SV) for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. The first GHRH analog to receive full US drug approval.

Tesamorelin1-2 mg · daily, subcutaneous
Discussion guide, not prescription

stack is an exploration engine. Output is a discussion guide for a conversation with a licensed provider — never a prescription, dose recommendation, or sourcing instruction. Peptides discussed include compounds with limited human evidence and varying legal status by jurisdiction. Verify everything with a qualified clinician before any decision.

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